Progression of serous ovarian tumor of low malignant potential to invasive serous carcinoma: a case report
نویسندگان
چکیده
Serous borderline ovarian tumors (SBOTs) represent group of tumors with cellular atypia and absent stromal invasion. Many studies support that SBOTs share similar molecular and genetic alterations with low-grade serous carcinomas, while high-grade serous carcinomas have a distinct pathway to carcinogenesis. Here we present a 55-year-old woman who underwent exploratory laparotomy and maximal debulking for SBOT. First recurrence was SBOT while second recurrence was low-grade invasive serous carcinoma. Recent molecular studies showed that molecular alterations detected in SBOTs were also present in low-grade serous carcinomas. In this manner, ovarian low-grade serous carcinomas are thought to evolve in a step-wise fashion from benign serous cystadenoma to SBOT and finally low-grade invasive serous carcinoma.
منابع مشابه
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